Laterality: Right-Sided and Left-Sided Colon Cancer

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Laterality: Right-Sided and Left-Sided Colon Cancer

Colorectal cancer (CRC) can be characterized by the location of the primary tumor being within the colon [1]. Right-sided colon cancer (RCC) is derived from the embryologic midgut, including the proximal two-thirds of the transverse colon, ascending colon, and cecum. Left-sided colon cancer (LCC) is derived from the embryologic hindgut, which includes the distal third of the transverse colon, s...

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Right-sided vs left-sided colorectal cancer.

AV In the analysis of the Cancer and Leukemia Group B (CALGB)/SWOG 80405 trial that we presented at the 2016 annual meeting of the American Society of Clinical Oncology (ASCO), we defined right-sided colon cancer as cancer of the cecum and the ascending colon up to the hepatic flexure. Left-sided colon cancer comprises cancer of the splenic flexure and cancer in regions distal to the splenic fl...

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A nationwide Danish cohort study challenging the categorisation into right-sided and left-sided colon cancer

OBJECTIVES The categorisation of colon cancer (CC) into right-sided (RCC) and left-sided (LCC) disease may not capture more subtle variances in aetiology and prognosis. In a nationwide study, we investigated differences in clinical characteristics and survival of RCC versus LCC and of the complete range of CC subsites. DESIGN Prospective nationwide cohort study. SETTING The database of the ...

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Right-sided colon cancer and left-sided colorectal cancers respond differently to cetuximab.

INTRODUCTION Right-sided colon cancer (RSCC) and left-sided colorectal cancer (LSCRC) differ with respect to their biology and genomic patterns. This study aimed to examine whether the primary tumor location is associated with the response to cetuximab in patients with metastatic colorectal cancer (mCRC). METHODS Patients with mCRC treated with cetuximab and standard chemotherapy as first- or...

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Tumor sidedness has emerged as an important prognostic and predictive factor in the treatment of colorectal cancer. Recent studies demonstrate that patients with advanced right-sided colon cancers have a worse prognosis than those with left-sided colon or rectal cancers, and these patient subgroups respond differently to biological therapies. Historically, management of patients with metastatic...

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ژورنال

عنوان ژورنال: Annals of Coloproctology

سال: 2017

ISSN: 2287-9714,2287-9722

DOI: 10.3393/ac.2017.33.6.205